th22 cells contribution in immunopathogenesis of rheumatic diseases

نویسندگان

gholamreza azizi imam hassan mojtaba hospital, alborz university of medical sciences, karaj, iran

anita simhag karolinska institutet science park ab, huddinge, sweden

nadia m-m-el rouby department of histology, dubai medical college, dubai, uae

abbas mirshafiey department of immunology, school of public health, tehran university of medical sciences, tehran, iran

چکیده

newly  identified  t  helper  cell  22  (th22)  is  a  subset  of  cd4+t  cells  with  specific properties apart from other known cd4+ t cell subsets with distinguished gene expression and function. th22 cells are characterized by production of a distinct profile of effector cytokines, including interleukin (il)-22, il-13, and tumor necrosis factor-α (tnf-α). the levels of th22 and related cytokine il-22 are increased in various autoimmune diseases and positively associated with some rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematosus, behcet's disease, ankylosing spondylitis and psoriatic arthritis. in summary, il-22 and th22 cells play a significant and complicated role in inflammatory and autoimmune  rheumatic  diseases,  therefore,  targeting  il-22  or  th22  have  unique  and attractive advantages due to the fact that th22 subset is recently identified and its associated research is extremely limited. this review discusses the role of th22 and its cytokine il-22 in the immunopathogenesis of rheumatic disease.

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عنوان ژورنال:
iranian journal of allergy, asthma and immunology

جلد ۱۴، شماره ۳، صفحات ۲۴۶-۲۵۴

کلمات کلیدی
[ ' i l ' , 2 2 , ' r h e u m a t i c d i s e a s e ' , ' r h e u m a t o i d a r t h r i t i s ' , ' s y s t e m i c l u p u s e r y t h e m a t o s u s ' , ' t h 2 2 ' ]

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